The word(s) "affair" appears 54 time(s) in 50 verse(s) in Quran in Mohsin Khan translation.

(31) The true believers are only those, who believe in (the Oneness of) Allah and His Messenger (Muhammad صلى الله عليه وسلم): and when they are with him on some common matter, they go not away until they have asked his permission. Verily those who ask your permission, those are they who (really) believe in Allah and His Messenger. So if they ask your permission for some affairs of theirs, give permission to whom you will of them, and ask Allah for their forgiveness. Truly, Allah is Oft-Forgiving, Most Merciful.

(32) Have you (O Muhammad صلى الله عليه وسلم) seen him who has taken as his ilah (god) his own vain desire? Would you then be a Wakil (a disposer of his affairs or a watcher) over him?

(33) "So I fled from you when I feared you. But my Lord has granted me Hukm (i.e. religious knowledge, right judgement of the affairs and Prophethood), and made me one of the Messengers.

(34) My Lord! Bestow Hukm (religious knowledge, right judgement of the affairs and Prophethood) on me, and join me with the righteous.

(35) And when he attained his full strength, and was perfect (in manhood), We bestowed on him Hukm (Prophethood and right judgement of the affairs) and religious knowledge [of the religion of his forefathers i.e. Islamic Monotheism]. And thus do We reward the Muhsinun (i.e. good doers. See the footnote of V.9:120).

(36) He manages and regulates (every) affair from the heavens to the earth; then it (affair) will go up to Him, in one Day, the space whereof is a thousand years of your reckoning (i.e. reckoning of our present world's time).

(37) And put your trust in Allah, and Sufficient is Allah as a Wakil (Trustee, or Disposer of affairs).

(38) And obey not the disbelievers and the hypocrites, and harm them not (in revenge for their harming you till you are ordered). And put your trust in Allah, and Sufficient is Allah as a Wakil (Trustee, or Disposer of affairs). [Tafsir Al-Qurtubi]

(39) Say: "Our Lord will assemble us all together (on the Day of Resurrection), then He will judge between us with truth. And He is the Just Judge, the All-Knower of the true state of affairs [Tafsir Ibn Kathir]

(40) Verily, We have sent down to you (O Muhammad صلى الله عليه وسلم) the Book (this Qur'an) for mankind in truth. So whosoever accepts the guidance, it is only for his ownself, and whosoever goes astray, he goes astray only for his (own) loss. And you (O Muhammad صلى الله عليه وسلم) are not a Wakil (trustee or disposer of affairs, or guardian) over them.